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According to the Surgeon General, Nearly all first use of cigarettes occurs by 18 years of age (88%). Reducing the percentage of adolescents who use tobacco is a major objective of the plan (Figure 2)

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In smokers, a single dose of the xanthine oxidase inhibitor allopurinol restores the acetylcholine-induced endothelium-dependent relaxation response in forearm arteries to nonsmoker levels but does not affect the endothelium-dependent relaxation response in nonsmokers [73]